摘要：日的探讨不稳定性心绞痛(UAP)患者白细胞介素一6(IL一6)及高敏C反应蛋白(hs—CRP)的变化及其临床意 义。方法 连续选择uAP患者64例(UAP组)，同期检查的稳定性心绞痛患者66倒(SAP组)，分析两组患者冠 心病危险因素及血浆11．-6和hs—CRP水平。结罩 UAP组患者的空腹血糖、收缩压、TC、LDL—C、吸烟指数、血浆 II．一6和hs—CRP浓度均明显高于sAP组。logistic逐步回归分析显示，血浆1L一6和hs—CRP浓度与UAP呈显著正 相关。直线相关分析，UAP患者的血浆IL一6、hs—CRP水平与冠状动脉狭窄程度和Gensini积分呈显著正相关，同 时UAP患者血浆IL一6和hs—CRP水平之间也具有直线相关性。结论 炎性因子IL一6与hs—CRP是UAP发病的 独立危险因素。 关键词：心绞痛，不稳定型；白细胞介素6；C反应蛋白质；冠状动脉疾病；危险因素 中图分类号：R541．4 文献标识码：A 文章编号：1009—0126(2008)06—0434—03
Changesofplasmainterlekin‘-6 andhigh sensitivityC··reactiveproteininpatientswith unstableangina pectorisWANG Shou—li，HAN Ya—ling，LIU Li-jun (Department of Cardiology，General Hospital of Shenyang Military Region，Shenyang110016，China) Abstract：-ive Toinvestigatethe - and clinicalsignificancesof interlekin一6(IL一6) and high sensitivityC—reactive protein(hs—CRP)in patients with unstable angina pectoris(UAP)． Methods 130 consecutive patients diagnosed asangina pectoris by coronary angiography were se— lected．Amongthem there were 64patientswith UAP and 66patientswith stableangina pectoris (SAP)．The serum levels of IL一6 and hs—CRP were measured．Results The mean serum levels offasting plasma glucose，total cholesterol，low density lipoprotein cholesterol，smoking index， plasma IL一6，hs—CRP level and systolic blood pressure in UAP group were significantly higher than those in SAPgroup．Logistic regression analysisof the 7 outcomeparametersrevealed that serum levels of hs—CRP and IL-6 were positively correlated to UAP．Linear regression analysis showed that serum levels of hs—CRP and IL一6 were positivelycorrelated with severity or areas of coronary artery stenosis and Gensini score，and serum level ofhs—CRP was positively correlated to serum level of IL一6 in UAPpatients．Conclusion Inflammatoryfactors IL一6 and hs—CRPmaybe independent risk factors for UAP． Key words：angina，unstable；interleukin一6；C—reactive protein；coronary disease；risk factors 慢性炎症是动脉粥样硬化(AS)发生、发展的重 要组成部分，白细胞介素一6(IL-6)被认定为炎性反 应的中枢性调节因子m引，而高敏C反应蛋白 (hs—CRP)是炎性反应主要血液标记物‘3~5]。
不稳 定性心绞痛(UAP)是介于稳定性心绞痛(SAP)和 急性心肌梗死间的一种心肌缺血症候群。我们分析 了UAP患者各种危险因素，并与SAP患者比较， 现报道如下。
1资料与方法
1．1 研究对象 选择2005年10月～2006年1月 在沈阳军区总医院心内科住院的冠心病患者。
纳入 标准：
(1)符合1979年WHO有关“缺血性心脏病的 命名和诊断标准”中UAP的诊断标准；
(2)愿意接 受冠状动脉造影和相关实验室检查。
排除标准：
(1) 心肌梗死；
(2)严重慢性心力衰竭，且LVEF